Oral desmopressin in neonatal diabetes insipidus.
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چکیده
منابع مشابه
Oral desmopressin in central diabetes insipidus.
Seven paediatric patients with central diabetes insipidus were studied in an open dose ranging study in hospital followed by a six month study on an outpatient basis to assess the efficacy and safety of peroral administration of DDAVP (desmopressin) tablets. In the dose ranging study a dose dependent antidiuretic response was observed. The response to 12.5-50 mcg was, however, less effective in...
متن کاملDesmopressin for nocturnal enuresis in nephrogenic diabetes insipidus.
We have investigated two unrelated families, in which two children had inherited primary nocturnal enuresis, and nephrogenic diabetes insipidus caused by new mutations in the aquaporin-2 gene (AQP2). The mutant AQP2 proteins were inactive, suggesting that administration of desmopressin could not concentrate the urine in these patients. However, treatment with desmopressin resolved primary noctu...
متن کاملComparison of incidence of hyponatremia between intranasal and oral desmopressin in patients with central diabetes insipidus.
Central diabetes insipidus (CDI), which is characterized by polyuria and polydipsia, is caused by a deficiency of the antidiuretic hormone arginine vasopressin (AVP). While CDI is treated with desmopressin, an analogue of AVP, the intranasal formulation is inconvenient and CDI patients reportedly prefer the oral formulation to the intranasal one. In Japan, intranasal desmopressin had been the o...
متن کاملDiabetes insipidus and the use of desmopressin in hospitalised children.
There have been recent concerns raised about the hospital care of patients with diabetes insipidus and the morbidity and mortality associated with delay or omission of administration of desmopressin. This is a review of diabetes insipidus and desmopressin with a practical guide to management of these complex patients for the general paediatrician or intensive care physician caring for these chi...
متن کاملEfficacy of Hydrochlorothiazide and low renal solute feed in Neonatal Central Diabetes Insipidus with transition to Oral Desmopressin in early infancy
BACKGROUND The treatment of central diabetes insipidus (DI) with desmopressin in the neonatal period is challenging because of the significant risk of hyponatremia with this agent. The fixed anti-diuresis action of desmopressin and the obligate high fluid intake with milk feeds lead to considerable risk of water intoxication and hyponatremia. To reduce this risk, thiazide diuretics, part of the...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1987
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.62.11.1177